Anti-Human CTGF Recombinant Antibody (TAB-443CQ)
CAT#: TAB-443CQ
Recombinant monoclonal antibody to CTGF. This antibody is a human monoclonal antibody that binds to connective tissue growth factor (CTGF). It inhibits CTGF.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 Anti-Human CTGF Recombinant Antibody (TAB-443CQ) in SDS-PAGE
SDS-PAGE analysis of TAB-443CQ in non-reduced (Lane 1) and β-mercaptoethanol-reduced (Lane 2) conditions.
SEC-HPLC
Figure 2 Anti-Human CTGF Recombinant Antibody (TAB-443CQ) in HPLC
The purity of TAB-443CQ was greater than 95% as determined by SEC-HPLC.
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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31074/564_D9_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human stomach, upper
Immunohistochemical staining of human stomach, upper shows moderate positivity in plasma and stromal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31075/ihc_selected.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_A_9_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_B_7_5.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_A_8_4.jpg
Normal Tissue
Figure 6 Smooth muscle
Smooth muscle cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5123/15554_B_5_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (EFO-21, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118523-CTGF
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1, κ
- Specificity
- Human CTGF
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, Inhib
- Conjugate
- Unconjugated
- Related Disease
- Duchenne muscular dystrophy, Hepatic fibrosis, Idiopathic pulmonary fibrosis, Pancreatic cancer
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The CTGF antibody has been reported in applications of PK , IHC, WB, ELISA, IF.
Target
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Reliable Results Every Time
Utilizing the anti-Human CTGF Recombinant Antibody has significantly increased the reliability of our experimental results. Its reproducible performance across various assays, including ELISA and IHC, allows us to consistently produce high-quality data. The specificity for CTGF without cross-reaction issues makes it an invaluable part of our research toolkit, especially in fibrotic disease studies.
Perfect for Cancer Pathway Exploration
Our research focuses on cancer biomarkers, particularly in pancreatic and ovarian cancer. This antibody's precise targeting of CTGF allows us to delve deeper into tumor microenvironment interactions. It has been instrumental in highlighting CTGF's role in metastasis, aiding in our understanding of potential therapeutic targets.
Strong Support for Fibrosis Pathway Research
This antibody has been pivotal in elucidating CTGF's role in fibrosis pathways. Whether through ELISA or Western blot, it consistently demonstrates CTGF's presence and variation, which is essential for understanding fibrosis development and progression in hepatic disease models.
Q&As
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Can this antibody be used for studies on fibrosis?
A: Absolutely. The CTGF protein is a key player in fibrosis, and this antibody can be used to study its role and modulation in pathological fibrosis in tissues such as liver (hepatic fibrosis) and lungs (idiopathic pulmonary fibrosis).
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What is the primary target of this antibody?
A: This antibody targets the Connective Tissue Growth Factor (CTGF), also known as CCN2. CTGF is involved in several cellular processes including cell adhesion, migration, proliferation, angiogenesis, and wound healing, making it a critical component for research in various fibrotic diseases and cancer.
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What applications can this antibody be used for?
A: This antibody is versatile and can be used in ELISA, Immunohistochemistry (IHC), Flow Cytometry (FC), Immunoprecipitation (IP), and Immunofluorescence (IF) assays, facilitating a broad range of experimental designs in cellular and molecular biology research.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-443CQ, RRID: AB_3111948)
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Biosimilar Overview
Please refer to Pamrevlumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Pamrevlumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "CTGF"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1576z | Mouse Anti-CTGF Recombinant Antibody (clone 32G9) | ELISA, IHC | Mouse IgG1 |
| HPAB-0181-YC | Human Anti-CTGF Recombinant Antibody (HPAB-0181-YC) | ELISA, FuncS | Human IgG |
| MRO-1793-CN | Rabbit Anti-CTGF Polyclonal Antibody (MRO-1793-CN) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-194CL | Anti-Human CTGF Recombinant Antibody (TAB-194CL) | WB, IHC, IF | Antibody |
| TAB-081MZ | Human Anti-CTGF Recombinant Antibody (TAB-081MZ) | ELISA | Human IgG |
| TAB-082MZ | Human Anti-CTGF Recombinant Antibody (TAB-082MZ) | ELISA | Human IgG |
| TAB-081MZ-S(P) | Human Anti-CTGF Recombinant Antibody; scFv Fragment (TAB-081MZ-S(P)) | ELISA | Human scFv |
| TAB-082MZ-S(P) | Human Anti-CTGF Recombinant Antibody; scFv Fragment (TAB-082MZ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-080MZ | Mouse Anti-CTGF Recombinant Antibody (TAB-080MZ) | ELISA | Mouse IgG |
| TAB-080MZ-S(P) | Mouse Anti-CTGF Recombinant Antibody; scFv Fragment (TAB-080MZ-S(P)) | ELISA | Mouse scFv |
| TAB-080MZ-F(E) | Mouse Anti-CTGF Recombinant Antibody; Fab Fragment (TAB-080MZ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-119LC | Recombinant Anti-Human CTGF Antibody (Fc glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0181-YC-S(P) | Human Anti-CTGF Recombinant Antibody; scFv Fragment (HPAB-0181-YC-S(P)) | ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0181-YC-F(E) | Human Anti-CTGF Recombinant Antibody; Fab Fragment (HPAB-0181-YC-F(E)) | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-443CQ | Afuco™ Anti-CTGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-443CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY573 | Anti-CTGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY1759 | Anti-Human CTGF Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY95 | Human Anti-CTGF scFv-Fc Chimera (VS-0425-FY95) | ELISA | Human IgG1, scFv-Fc |
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